Treatment is currently symptomatic, aimed at improving the presenting neuropsychiatric symptoms, with a special warning for the cautious use of neuroleptic medications as they may exacerbate extrapyramidal symptoms. No correlation has been identified between age of onset, extent of calcium deposits, and neurological deficits. Computerized tomography is superior to magnetic resonance imaging for radiological diagnosis. Seizures of various types frequently occur, some individuals experience chronic headache and vertigo. Neuropsychiatric symptoms, often the first or most prominent manifestation, range from mild difficulty with concentration and memory, to changes in personality and/or behavior, psychosis and dementia. Most affected individuals are in good health during childhood and young adulthood and typically present in the fourth to fifth decade with gradually progressive neuropsychiatric and movement disorders. Primary brain calcification (PBC) is a neurodegenerative disorder with characteristic calcium deposits in the basal ganglia and other brain areas, visualized by neuroimaging, without defined cause (formerly known as idiopathic brain calcification) and also without the autosomal dominant pattern of inheritance seen in primary familial brain calcification (also known as Fahr’s disease). This case report highlights the successful use of quetiapine for symptomatic treatment of acute psychosis due to PBC in an adolescent without exacerbating extrapyramidal symptoms. All the symptoms apart from lower intellectual abilities improved with quetiapine and sertraline. No causative mutations were found in selected genes. Other causes of brain calcification were excluded. Massive calcinations in the area of the basal ganglia and thalamus were determined by computerized tomography. Among others, the presentation included tactile hallucinations with secondary hypochondriacal delusions, which are rarely described in this diagnosis. The case of an adolescent female with acute psychotic symptoms, emotional instability, disorganized and suicidal behavior, stereotypical movements, below average intelligence and a three-year history of headaches is reported. We present the case of a patient with psychiatric manifestations much earlier than usual, in the second decade of life. 2015 12(7-8):12-9.Primary brain calcification (PBC), a neurodegenerative disorder with characteristic calcium deposits in the basal ganglia and other brain areas, typically presents with various neurological and psychiatric symptoms in the fourth or fifth decade of life or later. Efficacy of transcranial magnetic stimulation (TMS) in the treatment of schizophrenia: A review of the literature to date. FDA approves first drug to treat hallucinations and delusions associated with Parkinson’s disease.Ĭole JC, Green Bernacki C, Helmer A, Pinninti N, O'reardon JP. Hallucinations: Common features and causes. National Institute of Mental Health (NIMH). Hallucinations in healthy older adults: An overview of the literature and perspectives for future research. Hallucinations.īadcock JC, Dehon H, Larøi F. Hallucinations and delusions as low-quality attributions: Influencing factors and proposal for their analysis. Rodríguez-Testal JF, Senín-Calderón C, Moreno R. Hallucinations: Clinical aspects and management.
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